Journal of the American Academy of Dermatology
-
J. Am. Acad. Dermatol. · Jul 1987
Treatment of chronic postherpetic neuralgia with topical capsaicin. A preliminary study.
Continuing pain following herpes zoster is common in patients 60 years of age or older. Current treatments are generally unsatisfactory. The endogenous neuropeptide substance P is an important chemomediator of nociceptive impulses from the periphery to the central nervous system and has been demonstrated in high levels in sensory nerves supplying sites of chronic inflammation. ⋯ Of the 12 patients completing this preliminary study, 9 (75%) experienced substantial relief of their pain. The only adverse reaction was an intermittent, localized burning sensation experienced by one patient with application of capsaicin. Although these results are preliminary, they suggest that topical application of capsaicin may provide a useful approach for alleviating postherpetic neuralgia and other syndromes characterized by severe localized pain.
-
J. Am. Acad. Dermatol. · Mar 1987
Randomized Controlled Trial Comparative Study Clinical TrialSafety and efficacy of topical minoxidil in the management of androgenetic alopecia.
Of 149 subjects with androgenetic alopecia, 102 completed 1 year of a double-blind, randomized study comparing 2% minoxidil and 3% minoxidil solutions for safety and efficacy. One third of the subjects used a vehicle placebo for the first 4 months and then switched to 3% minoxidil. At 12 months the 2% minoxidil group switched to a 3% solution. ⋯ Two instances of allergic contact dermatitis and four of pruritus were attributed to use of the drug. Two individuals complained of impotence, which disappeared within a few days of discontinuation of topical minoxidil. This effect has not been reported during the use of minoxidil in its oral form (Loniten) for the treatment of hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
-
J. Am. Acad. Dermatol. · Mar 1987
Randomized Controlled Trial Clinical TrialTopical treatment for moccasin-type tinea pedis.
Sixty patients were treated for tinea pedis with 2% topical ketoconazole cream either once or twice daily. All diagnoses were confirmed mycologically. They were randomly assigned in a double-blind study into three groups on the basis of their clinical lesions, that is, vesicular pedis, interdigital pedis, and hyperkeratotic "moccasin" pedis. ⋯ The high percent of clinical efficacy seen in the first two groups corroborates treatment experiences held by most practicing dermatologists. Of practical interest, however, was the high number of responders among the moccasin-type of tinea pedis. Dermatologists rarely consider topical treatment useful for this clinical entity.
-
J. Am. Acad. Dermatol. · Feb 1987
Case ReportsToxic epidermal necrolysis: an approach to management using cryopreserved allograft skin.
Toxic epidermal necrolysis is an acute exfoliation of skin simulating a scald injury. Drug-induced toxic epidermal necrolysis has a mortality of greater than 50%. We report an 8-year-old girl with drug-induced toxic epidermal necrolysis who was treated with cryopreserved cadaver skin, with good outcome. ⋯ Graft keratinocytes demonstrated epiboly as reepithelialization by the host occurred along the host/graft interface. Host epidermis regenerated rapidly, presumably from adnexae, and displaced the viable allograft along the plane of the host/graft interface. The new epidermis appeared normal in all respects.
-
J. Am. Acad. Dermatol. · Jan 1987
Case ReportsDiffuse, progressive hyperpigmentation: an unusual skin manifestation of mycosis fungoides.
Pigmentary changes in mycosis fungoides usually occur in association with poikiloderma atrophicans vasculare or following therapy and regression of lesions. Several cases of hypopigmented mycosis fungoides have also been reported. ⋯ Giant melanin granules were found in the tumor cells, as well as in keratinocytes and Langerhans cells. As far as we know, this is the first report of cutaneous hyperpigmentation as a single presenting sign of mycosis fungoides.