The Journal of infection
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The Journal of infection · Apr 2006
Case ReportsTreatment of prosthetic valve infective endocarditis due to multi-resistant Gram-positive bacteria with linezolid.
Clinical experience with linezolid in the treatment of infective endocarditis either alone or in combination with other agents is limited. We describe our experience in the treatment of two patients with IE due to multi-resistant Gram-positive bacteria. ⋯ Although bacteriostatic, linezolid provides an important therapeutic option in IE due to multi-resistant Gram-positive pathogens. It challenges the conventional wisdom that bactericidal synergy is required for the effective treatment of most cases of IE due to Gram-positive organisms.