The Journal of infection
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The Journal of infection · Aug 2006
Epidemiology, risk factors and outcome of nosocomial infections in a Respiratory Intensive Care Unit in North India.
To determine the epidemiology, risk factors and outcome of infections in a Respiratory Intensive Care Unit (RICU) of a tertiary care institute in northern India. ⋯ This study clearly documents a high prevalence rate of infections in the ICU, and the data suggest that occurrence of infections was associated with a prolonged ICU stay but had no significant effect on the final outcome.
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There is an increasing interest in antibacterial products intended for applications, such as in carpets, hand lotions, wallpaper adhesives, gloves and fabrics used in the home and hospital environments. A range of materials impregnated with various types of antimicrobial agents, such as triclosan and silver-zeolite additive is also being evaluated for use in plastics, air filters, toys, tooth-brushes, pagers and telephones. However, there is not enough microbiological data to suggest the need for sterilization of telephones and similar hand-contact objects. ⋯ These results showed that public telephones are contaminated with various types of microorganisms and the level of contamination changes significantly with time.
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The Journal of infection · Aug 2006
Efficacy of amphotericin B or amphotericin B-intralipid in combination with caspofungin against experimental aspergillosis.
Infections caused by Aspergillus species are increasing in importance, especially among immunocompromised hosts. The objective of this study was to evaluate the efficacy of combination treatment consisting of the polyene amphotericin B (AMB) or amphotericin B-intralipid admixture (AMB-IL) and the echinocandin caspofungin (CAS) in experimental murine systemic aspergillosis. Inhibition of synthesis of a major component of the fungal cell wall and an effect on the cell membrane, by combining echinocandin and a polyene, may result in a synergistic interaction in vitro and in vivo against Aspergillus fumigatus. ⋯ The successful results obtained in the experimental animal model of this study may possibly open the way to more effective management of aspergillosis in humans.