The Journal of infection
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The Journal of infection · Jul 2014
Review Meta AnalysisAntibiotic prophylaxis for preventing recurrent cellulitis: a systematic review and meta-analysis.
A significant proportion of patients who have had a first episode of erysipelas or uncomplicated cellulitis will subsequently develop a recurrence. There is disagreement about how effective antibiotic prophylaxis is for preventing recurrent cellulitis. ⋯ Antibiotic prophylaxis can prevent recurrent cellulitis. Future research should aim to identify the ideal type, dosage, and duration of antibiotics for prophylaxis, as well as to identify the group of patients who will benefit most from antibiotic prophylaxis.
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The Journal of infection · Jul 2014
Case ReportsUnique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong.
Human infections caused by avian influenza virus A(H7N9) re-emerged in late 2013. We reported the first Hong Kong patient without risk factors for severe A(H7N9) disease. ⋯ The A/Hong Kong/470129/2013 virus is a novel reassortant derived from A/Guangdong/1/2013 virus. The unique mutation PA L336M may enhance viral replication and therefore disease severity.
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The Journal of infection · Jul 2014
Review Meta AnalysisAntibiotic prophylaxis in hematopoietic stem cell transplantation. A meta-analysis of randomized controlled trials.
We performed a meta-analysis to evaluate the impact of systemic antibiotic prophylaxis in hematopoietic stem cell transplantation (HSCT) recipients. ⋯ Systemic antibiotic prophylaxis successfully reduced the incidence of infection. However, there was no significant impact on mortality. The clinical benefits of prophylaxis with fluoroquinolones were inconclusive because of the small number of clinical trials evaluated.