The Journal of infection
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The Journal of infection · Apr 2017
Review Meta AnalysisEmpirical mono- versus combination antibiotic therapy in adult intensive care patients with severe sepsis - A systematic review with meta-analysis and trial sequential analysis.
To assess benefits and harms of empirical mono- vs. combination antibiotic therapy in adult patients with severe sepsis in the intensive care unit (ICU). ⋯ This systematic review of RCTs with meta-analysis and TSA demonstrated no differences in mortality or other patient-important outcomes between empirical mono- vs. combination antibiotic therapy in adult ICU patients with severe sepsis. The quantity and quality of data was low without firm evidence for benefit or harm of combination therapy.
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The Journal of infection · Apr 2017
ReviewAssociation of weekend effect with early mortality in severe sepsis patients over time.
The aim of this study is to investigate the "weekend effect" and early mortality of patients with severe sepsis. ⋯ Patients with severe sepsis are more likely to die in the hospital if they were admitted on weekends than if they were admitted on weekdays.