The Journal of infection
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The Journal of infection · Jan 2016
Impact of antifungal prescription on relative distribution and susceptibility of Candida spp. - Trends over 10 years.
The incidence of Candida spp. infections is worrisome, particularly in critically ill patients. Previous reports suggested that increasing use of antifungal therapy might affect resistance profiles of invasive strains. The study objective was to describe the distribution resistance profile of Candida spp. strains, and to correlate it with antifungal consumptions within one ICU. ⋯ Previous history of antifungal prescription within an ICU influences Candida species distribution and susceptibility profile to antifungal agents. The significant selective pressure exerted by caspofungin and amphotericin B on C. glabrata is a concern.
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The Journal of infection · Oct 2015
Observational StudyThe role of live poultry movement and live bird market biosecurity in the epidemiology of influenza A (H7N9): A cross-sectional observational study in four eastern China provinces.
A new reassortant influenza A (H7N9) virus emerged early 2013 in eastern China. Exposure to H7N9 infected poultry at live bird markets (LBM) was implicated as the main risk factor for human infection. We aimed to identify the role of LBM biosecurity indicators and poultry movement in the affected areas. ⋯ LBM biosecurity and chicken movement played an important role in the emergence of H7N9. This study identified highly connected areas in eastern China which continue to report human infections highlighting candidate areas for more detailed epidemiological investigations.
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The Journal of infection · Aug 2015
Observational StudyIntravenous immunoglobulin use in septic shock patients after emergency laparotomy.
The role of intravenous immunoglobulin (IVIG) as an adjunctive treatment for abdominal sepsis remains controversial. ⋯ There may be no significant association between IVIG use and mortality in mechanically ventilated septic shock patients after emergency laparotomy.