The Journal of infection
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The Journal of infection · Sep 2006
Case ReportsAn unusually late presentation of neuroschistosomiasis.
Schistosomiasis is one of the most widespread parasitic infections in man. Neuroschistosomiasis, referring to schistosomal involvement of the central nervous system, is an uncommon but well recognised complication of schistosomal infection. The duration between time of infection and onset of neurological symptoms typically varies between weeks to months. We describe a case of transverse myelitis secondary to neuroschistosomiasis, presenting more than three years after the time of initial schistosomal infection, diagnosed and treated in the district general hospital setting.
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The Journal of infection · Sep 2006
Validation of a Pseudomonas aeruginosa porcine model of septic shock.
To develop a standardized bacteraemic porcine model of septic shock with cardiovascular and immunological profiles similar to those observed in human clinical states. ⋯ The control of the systolic pulmonary arterial pressure during a P. aeruginosa infusion leads to a hyperdynamic, reproducible cardiovascular profile similar to the one observed in human septic shock. Since the immunological profile of the inflammatory cytokines is also similar to the human one, this standardized porcine model appears to be appropriate for experimental research concerning sepsis.
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The Journal of infection · Aug 2006
Epidemiology, risk factors and outcome of nosocomial infections in a Respiratory Intensive Care Unit in North India.
To determine the epidemiology, risk factors and outcome of infections in a Respiratory Intensive Care Unit (RICU) of a tertiary care institute in northern India. ⋯ This study clearly documents a high prevalence rate of infections in the ICU, and the data suggest that occurrence of infections was associated with a prolonged ICU stay but had no significant effect on the final outcome.
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There is an increasing interest in antibacterial products intended for applications, such as in carpets, hand lotions, wallpaper adhesives, gloves and fabrics used in the home and hospital environments. A range of materials impregnated with various types of antimicrobial agents, such as triclosan and silver-zeolite additive is also being evaluated for use in plastics, air filters, toys, tooth-brushes, pagers and telephones. However, there is not enough microbiological data to suggest the need for sterilization of telephones and similar hand-contact objects. ⋯ These results showed that public telephones are contaminated with various types of microorganisms and the level of contamination changes significantly with time.
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The Journal of infection · Aug 2006
Efficacy of amphotericin B or amphotericin B-intralipid in combination with caspofungin against experimental aspergillosis.
Infections caused by Aspergillus species are increasing in importance, especially among immunocompromised hosts. The objective of this study was to evaluate the efficacy of combination treatment consisting of the polyene amphotericin B (AMB) or amphotericin B-intralipid admixture (AMB-IL) and the echinocandin caspofungin (CAS) in experimental murine systemic aspergillosis. Inhibition of synthesis of a major component of the fungal cell wall and an effect on the cell membrane, by combining echinocandin and a polyene, may result in a synergistic interaction in vitro and in vivo against Aspergillus fumigatus. ⋯ The successful results obtained in the experimental animal model of this study may possibly open the way to more effective management of aspergillosis in humans.