Therapeutic drug monitoring
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Vancomycin is eliminated by glomerular filtration, but current approaches to estimate kidney function in children are unreliable. The authors sought to compare the suitability of cystatin C (CysC)-based glomerular filtration rate equations with the most commonly used creatinine-based equation, bedside Schwartz, to estimate vancomycin clearance (CL). ⋯ CysC-based equations help better estimate vancomycin CL than bedside Schwartz in critically ill children.