Journal of clinical psychopharmacology
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J Clin Psychopharmacol · Dec 2006
Meta AnalysisDuloxetine: meta-analyses of suicidal behaviors and ideation in clinical trials for major depressive disorder.
Uncertainty regarding relationships of antidepressant treatment and suicidality encouraged systematic review of data on suicidal behaviors and ideation from Phase II and III clinical trials of duloxetine for major depressive disorder (MDD). ⋯ We found no evidence of an increased risk of suicidal behaviors or ideation during treatment with duloxetine compared with placebo in MDD patients. HAMD Item-3 suicidality scores had more improvement and less worsening of suicidal ideation with duloxetine than placebo.
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J Clin Psychopharmacol · Dec 2006
Letter Randomized Controlled TrialAntipsychotic treatment discontinuation among individuals with schizophrenia and co-occurring substance use.