Journal of clinical psychopharmacology
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J Clin Psychopharmacol · Feb 2008
Letter Case ReportsDuloxetine-induced cutaneous adverse reaction.
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J Clin Psychopharmacol · Dec 2007
Randomized Controlled Trial Comparative StudyClozapine and olanzapine are associated with food craving and binge eating: results from a randomized double-blind study.
The second generation antipsychotics clozapine and olanzapine frequently induce weight gain. Randomized studies investigating abnormal eating behavior (food craving, binge eating) possibly associated with weight gain are lacking. Thirty patients with schizophrenia, schizophreniform, or schizoaffective disorder were included in this randomized, double-blind, parallel study comparing abnormal eating behavior using a standardized scale, clinical efficacy using the Brief Psychiatric Rating Scale 0-6 and Clinical Global Impression-Severity scale, and tolerability of clozapine and olanzapine. ⋯ Olanzapine was more tolerable than clozapine; adverse events occurred significantly (P < 0.01) less frequently than in the clozapine group. These results suggest that both clozapine and olanzapine can induce food craving and binge eating, however, olanzapine possibly to a greater extent. Findings on clinical efficacy and safety are in accordance with previous reports.