American journal of kidney diseases : the official journal of the National Kidney Foundation
-
Gabapentin is an antiepileptic medication that also has been used for restless legs syndrome. The mechanism of action is unknown. ⋯ Two patients on short daily hemodialysis therapy developed neuromuscular symptoms and an elevation in creatine kinase levels after starting gabapentin therapy. To our knowledge, this is the first case report of an increase in creatine kinase level after the administration of gabapentin.