Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
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To review the epidemiology of serious ocular trauma presenting to Kasr El Aini Hospital, Cairo University. ⋯ The majority of ocular trauma in our population was due to assaultive injuries occurring mainly in males. Open globe injuries were more common than closed globe injuries, and globe lacerations were more common than ruptured globes. Open globe injuries, especially ruptured globes, had the worst visual outcomes. The initial visual acuity correlated well with the final visual acuity. Immediate and comprehensive medical care is mandatory for ocular trauma patients. Educating the public is essential if we wish to prevent eye injuries.
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Graefes Arch. Clin. Exp. Ophthalmol. · Feb 2008
Eye injuries in an Italian urban population: report of 10,620 cases admitted to an eye emergency department in Torino.
Ocular trauma has significant impact on the patient's future quality of life. Most of the hospital-based studies tend to underestimate the occurrence of minor ocular trauma. In Torino the large majority of patients with ocular trauma are referred to a single hospital with a 24-hour Emergency Department (Ospedale Oftalmico). This offers the unique opportunity to analyze minor and major traumatic injuries in an industrial Italian city. ⋯ Although most of the injuries seen in an Emergency Department in Italy were minor, they were associated with a significant morbidity. In Torino, most of the traumatic eye injuries occurred at work or at home. Preventive and informative measures are warranted to reduce the incidence and prevalence of eye casualties.
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Graefes Arch. Clin. Exp. Ophthalmol. · Feb 2008
Ophthalmologists, suicide bombings and getting it right in the emergency department.
The number and extent of worldwide suicide attacks has risen sharply in recent years. The objectives of this retrospective study are: to determine the prevalence and outcome of the victims who sustained ocular injury, to describe the activities of ophthalmologists in the setting of an emergency department (ED) receiving mass casualties of a suicide bombing attack and to illustrate some of the treatment obstacles that they encountered and the protocol. ⋯ Ocular trauma management under conditions of mass injuries requires special utilization of manpower and resources. Guidelines for efficacious patient management, description of the ophthalmologist's role, and the experience of one emergency facility are presented.
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Graefes Arch. Clin. Exp. Ophthalmol. · Feb 2008
Transplantation of cells from eye-like structures differentiated from embryonic stem cells in vitro and in vivo regeneration of retinal ganglion-like cells.
An embryonic stem (ES) cell-derived eye-like structure, made up of neural retinal lineage cells, retinal pigment epithelial (RPE) cells, and lens cells was constructed in our laboratory. We have shown that cells from these eye-like structures can be integrated into the developing optic vesicle of chicks. The purpose of this study was to determine whether the cells from these eye-like structures can differentiate into retinal ganglion cells (RGCs) when transplanted into the vitreous of an injured adult mouse retina. ⋯ These findings suggest that ES cell-derived eye-like structures contain cells that can differentiate into RG-like cells and regenerate a new RGC layer. These cells also appeared to be integrated into the retina and extend axon-like processes toward the optic nerve head.