Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
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Graefes Arch. Clin. Exp. Ophthalmol. · Jan 2017
Discontinuation of long-term adalimumab treatment in patients with juvenile idiopathic arthritis-associated uveitis.
The purpose of this study was to evaluate the discontinuation of adalimumab (ADA) treatment in patients with juvenile idiopathic arthritis-associated uveitis (JIAU). ⋯ The data show a good primary response to ADA in patients with refractory JIAU. Due to the increasing rate of adalimumab failure or adverse events during long-term treatment, further treatment options may be required.
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Graefes Arch. Clin. Exp. Ophthalmol. · Jan 2017
Randomized Controlled Trial Multicenter StudyDexamethasone intravitreal implant in retinal vein occlusion: real-life data from a prospective, multicenter clinical trial.
To evaluate the relationship between duration of macular edema associated with retinal vein occlusion (RVO) and the achievement of vision gain in patients receiving dexamethasone intravitreal implant (DEX implant) in real-world clinical practice, and to define patterns of use of DEX implant and its efficacy and safety in the treatment of patients with RVO in clinical practice. ⋯ DEX implant was effective in improving BCVA and central retinal thickness in patients with BRVO and CRVO in real-world clinical practice. The largest gains in BCVA over 6 months occurred in patients with recent onset macular edema, confirming the benefit of early treatment. DEX implant was well tolerated and had an acceptable safety profile.