Annales françaises d'anesthèsie et de rèanimation
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Recombinant human activated protein C (APC) might be the first pharmacological intervention which decreases mortality in the course of severe sepsis. Surviving Sepsis Campaign guidelines have recommended the use of APC with grade B level of proof. During sepsis, the APC pathway serves as a major system for controlling thrombosis inhibiting thrombin formation, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis. ⋯ The results of ENHANCE, a multicenter open trial, have confirmed the trends reported in the PROWESS trial. Evidence supporting the efficacy of APC in the management of severe sepsis is clearly assessed. However, several issues remain unsolved and require to be addressed as the appropriate use of the drug and its place with other adjunctive therapies directed the sepsis process.
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Ann Fr Anesth Reanim · Mar 2006
Case Reports[Hypothermia after spinal anaesthesia: implication of morphine?].
Spinal anaesthesia is the gold standard for elective caesarean section. This technique presents several adverse effects. ⋯ Because hypothermia is not predictable after spinal injection of morphine both monitoring of central temperature and active warming of the patients could be proposed. Naloxone has been proposed in a case of hypothermia related to spinal injection of morphine.
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Ann Fr Anesth Reanim · Mar 2006
Letter Case Reports[Easy tracheal intubation? Mallampati class zero airway].