Regulatory toxicology and pharmacology : RTP
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Regul. Toxicol. Pharmacol. · Dec 1996
Historical ArticleOrigins and causes of the problem: the regulatory context.
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Regul. Toxicol. Pharmacol. · Oct 1996
Chronic toxicity and carcinogenicity study of erythritol in rats.
The potential toxicity and carcinogenicity of erythritol, a low-calorie sugar substitute, were examined in Wistar Crl:(WI) WU BR rats. Groups of 50 rats of each sex consumed diets with 0, 2, 5, or 10% erythritol, or 10% mannitol, for a period of 104-107 weeks. To each of these main groups, two satellite groups of 20 males each were attached for interim kills after 52 and 78 weeks of treatment. ⋯ In conclusion, the toxicological profile of erythritol in rats resembles that of other polyols in several respects. Except for nephrocalcinosis, which is commonly seen in polyol-fed rats, no other treatment-related, morphological changes were observed in the kidneys. Evidence for a tumor-inducing or tumor-promoting effect of erythritol was not seen.