European journal of anaesthesiology
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Randomized Controlled Trial Clinical Trial
Testing and modelling the interaction of alfentanil and propofol on the EEG.
For total intravenous anaesthesia an opioid is often combined with a hypnotic. A supra-additive interaction has been reported for clinical signs such as loss of consciousness or loss of the eyelash reflex. This study investigated the type of interaction of alfentanil and propofol on the electroencephalogram. ⋯ The type of interaction between alfentanil and propofol on the electroencephalogram in the investigated dose range is additive. This gives the freedom and need to select the appropriate dosing ratio of alfentanil and propofol by other considerations.
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Randomized Controlled Trial Clinical Trial
Changes in gas concentrations in the Brandt endotracheal tube cuff during and after anaesthesia with nitrous oxide.
The mechanism underlying stable cuff pressure in the Brandt rediffusion endotracheal tube during anaesthesia with nitrous oxide is not fully understood. The present study assessed changes in gas concentrations in the cuff during and after nitrous oxide anaesthesia. ⋯ Small changes in the nitrous oxide concentration in the cuff contribute to a stable cuff pressure in the Brandt rediffusion system, but changes in carbon dioxide or oxygen concentrations have little effect.
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Randomized Controlled Trial Clinical Trial
Effect of bispectral index monitoring on sevoflurane consumption.
The bispectral index, a parameter derived from the electroencephalograph, has been shown to correlate with the loss of consciousness and sedation. This study was designed to assess the effects of bispectral index monitoring on sevoflurane and its recovery profiles. ⋯ Bispectral index monitoring during anaesthesia provides only a small advantage related to the need to monitor the depth of anaesthesia.