Current medical research and opinion
-
Randomized Controlled Trial Multicenter Study
Acute postoperative pain relief with immediate-release tapentadol: randomized, double-blind, placebo-controlled study conducted in South Korea.
To broaden the ethnic groups in which tapentadol IR is evaluated for treating acute postoperative pain to include Asians. ⋯ NCT01516008.
-
Randomized Controlled Trial Multicenter Study Comparative Study
The SimpleMix study with biphasic insulin aspart 30: a randomized controlled trial investigating patient-driven titration versus investigator-driven titration.
The study aimed to confirm the efficacy, through non-inferiority, of patient-driven versus investigator-driven titration of biphasic insulin aspart 30 (BIAsp 30) in terms of glycemic control assessed by HbA1c change. ⋯ Non-inferiority of patient-driven versus investigator-driven titration with regard to change from baseline to end-of-treatment HbA1c could not be confirmed. It is possible that a clinic visit 12 weeks after intensification of treatment with BIAsp 30 in patients with type 2 diabetes inadequately treated with basal insulin may benefit patient-driven titration of BIAsp 30. A limitation of the study was the relatively small number of patients recruited in each country, which does not allow country-specific analyses to be performed. Overall, treatment with BIAsp 30 was well tolerated in both treatment groups.
-
Although the need for combination therapy of hypertension was obvious from the early intervention trials, administration of such therapy as fixed-dose or single-pill combinations has only reached general acceptance in recent years. The main reason for this change of mind documented in the recommendation of using single-pill combinations in almost every recent hypertension guideline is our increasing knowledge about non-adherence to drug therapy. In the multifactorial origin of non-adherence, the complexity of therapy, especially in elderly patients with comorbidities and polypharmacy, has been identified as a major factor involved. So an important rule in hypertension treatment, and maybe in drug therapy in general, is to keep things as simple as possible.
-
Randomized Controlled Trial
Assessment of the safety and efficacy of extended-release oxycodone/acetaminophen, for 14 days postsurgery.
To investigate the safety and satisfaction of patients treated ≤ 14 days after unilateral bunionectomy with extended-release oxycodone/acetaminophen (ER OC/APAP), a biphasic (ER and immediate release) fixed-dose combination analgesic being developed for moderate to severe acute pain. ⋯ These results show that ER OC/APAP demonstrated an expected safety and tolerability profile and good patient satisfaction in a postsurgical model of acute pain.