Journal of critical care
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Journal of critical care · Jun 2021
Observational StudyMean amplitude of glycemic excursions in septic patients and its association with outcomes: A prospective observational study using continuous glucose monitoring.
To apply continuous glucose monitoring (CGM) and determine the mean amplitude of glycemic excursions (MAGE) in septic patients and to assess the associations of MAGE with outcomes and oxidative stress. ⋯ In the current study, MAGE for the first 48 h of treatment that was obtained by using CGM was associated with 90-day all-cause mortality, 90-day ICU-free days and urinary 8-isoprostaglandinF2α level in septic patients.
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Journal of critical care · Jun 2021
Bayesian analysis of the epidemiology of bleeding in critically ill children.
We updated our findings on the epidemiology of clinically relevant bleeding (CRB) in critically ill children. We also determined the concordance of CRB as defined by the International Society of Thrombosis and Haemostasis, i.e., ISTH definition, and characteristics identified by pediatric intensivists in a recent survey, i.e., survey definition. ⋯ Our updated findings highlight the high frequency of CRB regardless of definition used for CRB.
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Journal of critical care · Jun 2021
Clinical trial registry searches are under-utilized in systematic reviews from critical care journals: A bibliometric analysis.
Publication bias has a significant impact on the results of systematic reviews. Clinical trial registry searches, which include unpublished research, should be conducted when performing systematic reviews to reduce publication bias. We aimed to analyze the use of clinical trial registry searches in critical care systematic reviews. ⋯ The omission of relevant, unpublished clinical trial results may be negatively impacting the accuracy of critical care systematic reviews. We recommend all systematic reviewers conduct clinical trial registry searches to reduce publication bias.
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Journal of critical care · Jun 2021
Observational StudyCombination of delirium and coma predicts psychiatric symptoms at twelve months in critically ill patients: A longitudinal cohort study.
We aimed to determine any associations between delirium and comas during intensive care unit (ICU) stay, and long-term psychiatric symptoms and disability affecting activity of daily living (ADL). ⋯ In critically ill adults, combination of delirium and comas during ICU stay is a predictor of psychiatric symptoms or ADL disability.
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Journal of critical care · Jun 2021
Observational StudyInitial setting of high-flow nasal oxygen post extubation based on mean inspiratory flow during a spontaneous breathing trial.
High flow nasal cannula (HFNC) is commonly used post-extubation in intensive care (ICU). Patients' comfort during HFNC is affected by flow rate. The study aims to describe the relationship between pre-extubation inspiratory flow requirements and the post-extubation flow rates on HFNC that maximises patient's comfort. ⋯ Measuring mean inspiratory flow during an SBT allows for individualised setting of HFNC flow rate immediately post-extubation and achieves the greatest comfort and interface tolerance.