Journal of critical care
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Journal of critical care · Apr 2024
Brain magnetic resonance imaging findings six months after critical COVID-19: A prospective cohort study.
COVID-19 patients suffered from neurological symptoms in the acute phase. Whether this led to long-term consequences was unknown. We studied long-term brain MRI findings in ICU-treated COVID-19 patients and compared them with findings in groups with less severe acute disease. ⋯ Age and supplementary oxygen days were independently associated with CMBs; COVID-19 status showed no association. Accumulation of risk factors in the ICU group may explain the higher prevalence of CMBs.
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Journal of critical care · Apr 2024
Serial electrical impedance tomography course in different treatment groups; The MaastrICCht cohort.
To describe the effect of dexamethasone and tocilizumab on regional lung mechanics over admission in all mechanically ventilated COVID-19 patients. ⋯ Optimal and clinically applied PEEP were lower in the dexamethasone and dexamethasone + tocilizumab groups. The results suggest that the potential beneficial effects of these therapies do not affect lung mechanics favorably. However, this study cannot fully rule out any beneficial effect of anti-inflammatory treatment on pulmonary function due to its observational nature.
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Journal of critical care · Apr 2024
Dose equivalence for metaraminol and noradrenaline - A retrospective analysis.
Noradrenaline and metaraminol are commonly used vasopressors in critically ill patients. However, little is known of their dose equivalence. ⋯ The median dose equivalence for metaraminol and noradrenaline in this study was 12.5:1. However, there was significant variance in dose equivalence, only half the proportion of variation in noradrenaline infusion dose was predicted by metaraminol dose, and conversion-associated hypotension was common.
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Journal of critical care · Apr 2024
Prevalence of frailty and association with patient centered outcomes: A prospective registry-embedded cohort study from India.
We aimed to study the prevalence of frailty, evaluate risk factors, and understand impact on outcomes in India. ⋯ CTRI/2021/02/031503.