The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Jul 2002
Review Case ReportsChromobacterium violaceum infection in children: a case of fatal septicemia with nasopharyngeal abscess and literature review.
This previously healthy 5-year-old boy initially presented with fever and purulent conjunctivitis. The course evolved rapidly into preseptal and facial cellulitis, nasopharyngeal abscess and sepsis. ⋯ He received intravenous cefazolin therapy for 2 days, followed by penicillin, oxacillin and netilmicin. However, no improvement was noted, and he died on the fifth days of illness.
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Pediatr. Infect. Dis. J. · Jul 2002
Comparative StudyResponse to changes in antiretroviral therapy after genotyping in human immunodeficiency virus-infected children.
HIV genotyping has been beneficial when choosing salvage regimens in adults failing highly active antiretroviral therapy (HAART). Our objectives were to evaluate the usefulness of genotyping in HIVinfected children failing HAART and to determine whether the presence of resistance mutations was associated with previous antiretroviral therapy. ⋯ This study did not demonstrate substantial clinical benefit to HIV genotyping in antiretroviral agent-experienced pediatric patients with high viral loads. These results contrast with favorable short term clinical and virologic responses to therapeutic changes after genotyping in HIV-infected adults. However, medication history alone does not appear to be an adequate alternative to genotyping in choosing salvage regimens in antiretroviral agent-experienced children.
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Pediatr. Infect. Dis. J. · Jul 2002
Comparative StudyAcute otitis media in infants younger than two months of age: microbiology, clinical presentation and therapeutic approach.
Information on the causative agents of acute otitis media (AOM) in infants <2 months of age is limited. ⋯ (1) Most cases of AOM in infants <2 months of age are caused by pathogens similar to those causing AOM in older children; (2) antibiotic resistance may already be present at early age and should be considered in the empiric treatment of AOM in infants <2 months of age; (3) the presence of AOM does not predict a higher risk for serious bacterial infections in afebrile and febrile infants <2 months of age.