Critical care medicine
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Critical care medicine · Oct 1998
Liver as a focus of impaired oxygenation and cytokine production in a porcine model of endotoxicosis.
To determine whether the liver is a focus of insufficient oxygenation and whether liver is a source of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in a porcine model of endotoxicosis. ⋯ In this porcine model of endotoxicosis, there is a reduction of hepatic oxygen delivery but dysoxia is not present. The liver is not a source of TNF or IL-6 in this model of endotoxicosis.
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Critical care medicine · Oct 1998
Hypocapnia does not alter hepatic blood flow or oxygen consumption in patients with head injury.
To evaluate the effects of hypocapnia on the systemic and hepatic circulations and oxygenation values in patients with head injury. ⋯ Hypocapnic hyperventilation does not alter hepatic hemodynamic parameters in patients with head injury. This result may be related to the lack of changes in cardiac output or in the hepatic vasoreactivity. Moreover, hypocapnia does not modify hepatic-splanchnic oxygenation. Thus, in case of intracranial hypertension, hypocapnia might be used without undesirable effect on the hepatic-splanchnic perfusion.