Critical care medicine
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Critical care medicine · May 1998
Left ventricular performance following the arterial switch operation: use of noninvasive wall stress analysis in the postoperative period.
To determine postoperative left ventricular mechanics following the arterial switch operation (ASO). ⋯ Left ventricular performance is impaired in infants during the period immediately following the ASO. A persistent preload deficit closely matches the pattern of impaired ventricular performance. Decreased IVRT points to impaired ventricular compliance as the etiology of the altered preload. In contrast, left ventricular contractility remains normal in the majority of post-ASO patients. Decreased contractility may account for impaired ventricular performance in selected cases.
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Critical care medicine · May 1998
Comparative StudyExogenous interleukin-10 fails to decrease the mortality or morbidity of sepsis.
To determine if exogenous interleukin (IL)-10 will decrease the morbidity or mortality of sepsis induced by cecal ligation and puncture. ⋯ Our data indicate that exogenous IL-10 fails to improve morbidity or mortality in the clinically relevant cecal ligation and puncture model of sepsis.
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Critical care medicine · May 1998
Case ReportsProtein C in the treatment of coagulopathy in meningococcal disease.
To evaluate the clinical and laboratory effects of the substitution of protein C (PC) as an adjunct to conventional therapy in the treatment of purpura fulminans associated with meningococcal sepsis. ⋯ The administration of PC had a beneficial effect on coagulopathy and peripheral gangrene formation associated with meningococcal disease and showed no adverse effects.
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Critical care medicine · May 1998
Comment Letter Review Case ReportsRecombinant tissue plasminogen activator restores perfusion in meningococcal purpura fulminans.
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Critical care medicine · May 1998
Effects of partial liquid ventilation on lung injury in a model of acute respiratory failure: a histologic and morphometric analysis.
To compare the histopathologic changes observed in a sheep model of oleic acid-induced acute respiratory failure during partial liquid ventilation with perflubron with gas ventilation. ⋯ Partial liquid ventilation is associated with notable improvement in gas exchange and with a reduction in the histologic and morphologic changes observed in an oleic acid model of acute lung injury.