Critical care medicine
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Critical care medicine · Jun 2000
Intravenous crocetinate prolongs survival in a rat model of lethal hypoxemia.
To examine whether a carotenoid, trans-sodium crocetinate, has beneficial effects on hemodynamic status and short-term outcome in a rat model of lethal hypoxemia. ⋯ Trans-sodium crocetinate improved hemodynamic status and prolonged survival in this model of severe acute hypoxic hypoxia. To our knowledge, this is the first demonstration of an intravenous agent having such an effect.
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Critical care medicine · Jun 2000
The role of tumor necrosis factor in the development of multiple organ failure in a murine model.
To elucidate the role of tumor necrosis factor (TNF) in the development of multiple organ dysfunction syndrome (MODS) after zymosan-induced peritonitis in mice. ⋯ Organ-derived TNF-alpha plays a crucial role in the development of MODS in this murine model.