Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Oct 1996
Clinical Trial Controlled Clinical TrialInfluence of loperamide on lactose handling and oral-caecal transit time.
The influence of pharmacologically prolonged oral caecal transit time on lactose handling is examined in the wake of finding improved lactose handling during naturally occurring prolonged oral-caecal transit time. ⋯ Loperamide-induced graded prolongation of oral-caecal transit time is associated with significantly improved lactose handling as measured by a reduction of the area under the curve. Symptoms of lactose intolerance may also be improved with loperamide. Prolongation of oral-caecal transit time with loperamide may be useful as adjunctive or primary therapy of carbohydrate intolerance in patients with rapid transit.