Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Feb 1997
Comparative Study Clinical Trial Controlled Clinical TrialEffects of octreotide, a somatostatin analogue, on gastric function evaluated by real-time ultrasonography.
Somatostatin exerts inhibitory effects on physiological functions in the gastrointestinal tract. The actions differ, however, depending on the test meal, dose, and other factors. ⋯ Octreotide given with a liquid or solid meal inhibited gastric emptying in healthy subjects. A significant suppression of antral contraction occurred only with a solid meal.
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Aliment. Pharmacol. Ther. · Feb 1997
Randomized Controlled Trial Comparative Study Clinical TrialAntiemetic activity of ondansetron in acute gastroenteritis.
The mechanism of nausea and vomiting associated with gastroenteritis is unknown. The role of 5-HT3 receptors in emesis associated with gastroenteritis was investigated in paediatric patients. ⋯ Ondansetron, a 5HT3 receptor antagonist, was significantly superior to placebo in preventing emesis associated with acute gastroenteritis, in paediatric patients. Therefore, serotonin, acting through 5HT3 receptors, may play a role in this form of emesis.