Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Oct 2005
Multicenter StudyCoeliac disease case finding and diet monitoring by point-of-care testing.
Immunoglobulin A class transglutaminase autoantibodies are highly predictive markers of active coeliac disease, a disorder difficult to recognize solely on clinical grounds. ⋯ Point-of-care testing was accurate in finding new coeliac cases and helped to identify and decrease dietary non-compliance.
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Aliment. Pharmacol. Ther. · Oct 2005
Multicenter Study Clinical TrialLack of predictors of normalization of oesophageal acid exposure in Barrett's oesophagus.
Barrett's oesophagus patients may continue to have abnormal oesophageal acid exposure on proton pump inhibitor therapy. The effect of factors such as Barrett's oesophagus length, hiatal hernia size and Helicobacter pylori infection on intra-oesophageal pH in Barrett's oesophagus patients has not been adequately studied. ⋯ Approximately 25% of Barrett's oesophagus patients continue to have abnormal total intra-oesophageal pH profiles despite b.d. proton pump inhibitor therapy. Factors such as age, Barrett's oesophagus length and hiatal hernia size cannot be used to predict persistent abnormal intra-oesophageal pH on proton pump inhibitor.