Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Jan 2007
Meta AnalysisMeta-analysis: Alvimopan vs. placebo in the treatment of post-operative ileus.
Alvimopan is a selective, competitive mu-opioid receptor antagonist with limited oral bioavailability which may be used to reduce length of post-operative ileus. ⋯ Alvimopan showed significant advantages over placebo in restoring gastro-intestinal function, and reduced time to discharge following major abdominal surgery, with acceptable side effects.