Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Feb 2009
ReviewSystematic review: open, small-incision or laparoscopic cholecystectomy for symptomatic cholecystolithiasis.
Laparoscopic cholecystectomy has become the method of choice for gallbladder removal, although evidence of superiority over open and small-incision cholecystectomy is lacking. ⋯ No significant differences in mortality and complications were found among all three techniques. Laparoscopic cholecystectomy and small-incision cholecystectomy are preferred over open cholecystectomy for quicker convalescence. Laparoscopic cholecystectomy and small-incision cholecystectomy show no clear differences on patient outcomes.
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Aliment. Pharmacol. Ther. · Feb 2009
Randomized Controlled Trial Multicenter StudyClinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study.
Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL). ⋯ Over 12 weeks, prucalopride was effective and well tolerated in chronic constipation.
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Aliment. Pharmacol. Ther. · Feb 2009
Randomized Controlled Trial Multicenter StudyClinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studies.
Effective treatments for irritable bowel syndrome with constipation (IBS-C) are lacking. ⋯ The percentage of overall responders based on patient-rated assessments of IBS-C symptoms was significantly improved in patients treated with lubiprostone 8 mcg twice daily compared to those treated with placebo. Lubiprostone was well tolerated with a favourable safety profile.