Archives of gynecology and obstetrics
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Arch. Gynecol. Obstet. · Aug 2013
Randomized Controlled TrialEffects of gum chewing on recovery of bowel function following cesarean section: a randomized controlled trial.
To evaluate the effects of gum chewing on recovery of bowel function after cesarean section. ⋯ Gum chewing is associated with faster recovery of bowel function following cesarean section. It is safe, practical, inexpensive, and well tolerated.
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Arch. Gynecol. Obstet. · Aug 2013
Pregnancy outcome in women with pulmonary arterial hypertension: single-center experience from India.
A retrospective analysis of the records of all the patients of pulmonary arterial hypertension with pregnancy at AIIMS, New Delhi, India, to study maternal and perinatal outcome and to compare outcome between severe and mild pulmonary arterial hypertension. ⋯ Pregnancy in women with severe PAH is associated with higher maternal morbidity and adverse fetal outcome compared to pregnancy in women with mild PAH.
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Arch. Gynecol. Obstet. · Aug 2013
Abdominal electromyography in laboring and non-laboring pregnant women at term and its clinical implications.
To determine the patterns of uterine action potentials in laboring and non-laboring women at term using the non-invasive abdominal electromyography technique. ⋯ Abdominal electromyography may help to distinguish between women in true active labor from those who are not. It also may help to identify women who will enter into labor within 24-72 h and those who require augmentation of labor.
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Arch. Gynecol. Obstet. · Aug 2013
ReviewOlaparib: a promising PARP inhibitor in ovarian cancer therapy.
Ovarian cancer (OC) is the leading cause of death in women with gynecological cancer. Most patients are diagnosed at advanced stage with poor prognosis. Currently, surgical tumor debulking followed by chemotherapy based on platinum and taxane is the standard treatment for advanced OC. However, these patients remain at great risk for recurrence and developing drug resistance. Therefore, new treatment strategies are needed to improve outcomes for patients with advanced and recurrent OC. Olaparib (AZD2281, KU-0059436), as one of the best understood Poly-(ADP-ribose) polymerase (PARP) inhibitor targeting DNA repair mechanisms, caused more and more attention. Clinical trial data of Olaparib had been cumulated, which applied as the single-agent in relapsed OC monotherapy, especially for BRCA mutation associated OC. ⋯ Given the unprecedented clinical potential of Olaparib, the further research on Olaparib will have great significance in selection of OC patient populations that will respond to treatment.
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Arch. Gynecol. Obstet. · Aug 2013
Are there changes in characteristics and therapy of young patients with early-onset breast cancer in Germany over the last decade?
The objective of the study is to investigate recent changes in patient characteristics and treatment procedures of young breast cancer patients over the last 10 years in Germany. ⋯ Young breast cancer patients in Germany can still be regarded as a special group. Although tumors are now more often detected before reaching the lymph nodes than 10 years ago, an even bigger percentage is triple negative. Operative treatment has improved to a less aggressive way. Still operative and medical treatments have to be chosen after very careful evaluation.