BMJ : British medical journal
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To determine and compare the effects of drug prophylaxis on SARS-CoV-2 infection and covid-19. ⋯ This article is a living systematic review that will be updated to reflect emerging evidence. Updates may occur for up to two years from the date of original publication.
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To assess the methodological quality of individual participant data (IPD) meta-analysis and to identify areas for improvement. ⋯ The methodological quality of IPD meta-analyses is unsatisfactory. Future IPD meta-analyses need to establish an a priori protocol with prespecified data syntheses plan, comprehensively search the literature, critically appraise included randomised controlled trials with appropriate technique, account for risk of bias during data analyses and interpretation, and account for unavailable IPD.