European journal of gastroenterology & hepatology
-
Eur J Gastroenterol Hepatol · Dec 2010
Randomized Controlled Trial Multicenter StudyThe PreventCD Study design: towards new strategies for the prevention of coeliac disease.
PreventCD (www.preventcd.com) is a European multicentre study, which studies the influence of infant nutrition, and that of genetic, immunologic and environmental factors, on the risk of developing coeliac disease (CD). The hypothesis is that it is possible to induce tolerance to gluten by introducing small quantities of gluten to infants, preferably while they are still being breast-fed, and that this might also reduce the risk for related autoimmune disorders. ⋯ PreventCD is expected to elucidate some of the genetic and immunological mechanisms involved in the process of immune intolerance.
-
Eur J Gastroenterol Hepatol · Dec 2010
Short-term and long-term vital outcomes of cirrhotic patients admitted to an intensive care unit.
To evaluate short-term and long-term vital outcomes of cirrhotic patients admitted to a general ICU, to evaluate the prognostic value of severity scores and to identify risk factors associated with death. ⋯ ICU admission should not be ruled out for patients with complicated cirrhosis. Although common in cirrhotic patients, low plasma albumin level was the only factor independently associated with short-term and long-term mortalities.
-
Eur J Gastroenterol Hepatol · Sep 2010
Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis.
During abdominal sepsis, the activation of hepatic Kupffer cells (KC) and its consequences are of central interest. This study evaluates the impact of selective KC depletion on hepatic microcirculation, cytokine release, and systemic alterations in the colon ascendens stent peritonitis (CASP), a model of polymicrobial abdominal sepsis. ⋯ The results indicate that KC depletion is locally protective in polymicrobial abdominal sepsis, as it reduces hepatic inflammation and apoptosis. These effects could be observed in the presence of clearly elevated TNF levels. However, the lack of IL-10 in KC-depleted mice resulted in a detrimental systemic proinflammation.
-
Eur J Gastroenterol Hepatol · Aug 2010
A slow caloric satiety drinking test in patients with temporary and permanent gastric electrical stimulation.
Improvement of gastric accommodation has been proposed as a potential explanation for the positive effect of gastric electrical stimulation (GES) on nausea/vomiting. A drinking test has been suggested as a noninvasive measure of gastric accommodation capacity. ⋯ GES had no effect on proximal gastric function as evaluated by the slow caloric satiety drinking test. This seems to be the case for patients with approved as well as nonapproved indications for GES, and irrespective of the symptomatic response.
-
Eur J Gastroenterol Hepatol · Aug 2010
Listening to music does not reduce pain during sigmoidoscopy.
Up to 40% of the sigmoidoscopies are considered painful by patients. Nonpharmacological intervention would be attractive, as sedation and analgesia carry the risk of side-effects and increase procedure-related costs. Music might have the potential of pain reduction, but its effect during sigmoidoscopy has not been established yet. To study whether listening to music reduces experienced pain during sigmoidoscopy. ⋯ Listening to music by patients did not reduce pain intensity during sigmoidoscopy. As a consequence, music during sigmoidoscopy is not recommended for this purpose.