European journal of gastroenterology & hepatology
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Eur J Gastroenterol Hepatol · Dec 2009
Management of minor upper gastrointestinal haemorrhage in the community using the Glasgow Blatchford Score.
The Glasgow Blatchford Score (GBS) is a validated risk assessment tool in primary upper gastrointestinal haemorrhage, which accurately predicts the need for intervention (endoscopic therapy, blood transfusion or surgery) or death. ⋯ Using the criteria of a GBS
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Eur J Gastroenterol Hepatol · Nov 2009
Randomized Controlled TrialCost-effectiveness of adalimumab for the maintenance of remission in patients with Crohn's disease.
Adalimumab is a fully human, monoclonal antibody clinically effective for the treatment of active Crohn's disease. The cost-effectiveness of adalimumab versus conventional, nonbiologic pharmacotherapies is unknown. This study evaluated the cost-effectiveness of adalimumab versus conventional, nonbiologic pharmacotherapies in the maintenance of Crohn's disease. ⋯ Adalimumab maintenance therapy seems to be cost-effective versus conventional, nonbiologic therapies for the maintenance of remission in patients with active Crohn's disease.
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Eur J Gastroenterol Hepatol · Oct 2009
Is it reasonable to treat early gastric cancer with signet ring cell histology by endoscopic resection? Analysis of factors related to lymph-node metastasis.
Early gastric cancer (EGC) with signet ring cell histology has a more favorable prognosis than other undifferentiated gastric adenocarcinomas. The presence of lymph-node metastasis is the most important factor in treating EGC by endoscopic resection. The aim of this study was to identify the factors predicting successful endoscopic treatment of EGC with signet ring cell histology. ⋯ EGC with signet ring cell histology can be treated by endoscopic mucosal resection, if it is smaller than 25 mm, limited within the sm2 layer, and does not involve the lymphatic-vascular structure. More extensive prospective data are required to confirm definitive guidelines for the endoscopic treatment of patients with EGC with signet ring cell histology.
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Eur J Gastroenterol Hepatol · Aug 2009
Use of sedation in gastrointestinal endoscopy: a nationwide survey in Spain.
Gastrointestinal endoscopy causes discomfort and pain in patients. Sedation reduces anxiety and pain. Its use, however, continues to be a controversial issue and it varies greatly from one country to another. The use of sedation in Spanish gastrointestinal endoscopy (GIE) units is unknown. ⋯ The use of sedation in endoscopy varies greatly in Spain. It is seldom used in gastroscopy; it is more frequent in colonoscopy, and in ERCP it is the norm. In most GIE units sedation is controlled by the endoscopist with pulse oximetry. The most commonly used drugs are benzodiazepines, on their own for gastroscopy and combined with opioids for colonoscopy and ERCP.
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Eur J Gastroenterol Hepatol · Jul 2009
Comparative StudyCirrhotics admitted to intensive care unit: the impact of acute renal failure on mortality.
The exact role of renal dysfunction in critically ill cirrhotics admitted to an intensive care unit (ICU) has not been assessed extensively. ⋯ ARF at admission or during ICU stay is strongly predictive of mortality, which is high, despite supportive therapeutic interventions. Preventive measures are needed to prevent ARF, to improve prognosis.