Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Nov 2008
The endothelin receptor antagonist tezosentan improves renal microcirculation in a porcine model of endotoxemic shock.
Impaired renal microcirculation has been suggested as a factor contributing to the development of renal dysfunction in sepsis. This study was conducted to elucidate the role of endothelin-1 (ET-1)in mediating reductions in renal microcirculatory blood flow during endotoxemic shock. ⋯ These results indicate that treatment with the dual endothelin receptor tezosentan in endotoxemic shock attenuates the reduction of renal microcirculation and total renal blood flow independently of plasma changes in the renin-angiotensin-aldosterone system or early plasma cytokine response.