Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 2014
Controlled Clinical TrialIntrathecal fentanyl decreases the optimal effect site concentration of propofol during spinal anaesthesia.
The aim of this study was to assess the possible difference in the optimal effect site concentration of propofol for conscious sedation during spinal anaesthesia with or without intrathecal fentanyl in patients undergoing urologic surgery. The hypothesis was that intrathecal fentanyl would decrease the effect site concentration of propofol needed for conscious sedation. ⋯ The EC50 of the effect-site concentration of propofol for sedation decreased from 1.67 ± 0.28 mcg/ml to 0.87 ± 0.15 mcg/ml with the addition of 25 mcg fentanyl to a spinal anaesthetic in patients undergoing urologic surgery.