Acta neurologica Scandinavica
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Early administration of paracetamol may improve outcome of patients with acute stroke and a baseline body temperature of 37°C or above by lowering body temperature and preventing fever. Besides its antipyretic effects, paracetamol may affect blood pressure through cyclooxygenase-2 inhibition. We therefore aimed to assess the effect of high-dose paracetamol on blood pressure in patients with acute stroke. ⋯ High-dose paracetamol reduces not only body temperature but also systolic blood pressure in the first 12 h after start of treatment. Both effects may improve functional outcome after stroke, but this needs further study.
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The PFS-16 is a 16-item fatigue scale for Parkinson's disease (PD) developed in the UK. However, documented translations and psychometric evaluations are sparse. ⋯ These observations support the psychometric properties of the Swedish PFS-16, but cautions against dichotomised scoring.
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Acta Neurol. Scand. · Apr 2012
Animal model for sport-related concussion; ICP and cognitive function.
We have recently developed and characterized a rat model of mild traumatic brain injury which simulates the concussive injuries frequently encountered by players in American professional football. ⋯ Multiple impacts to the head raise intracranial pressure and impair cognitive function and exploratory activity in this animal model.