Bioorganic & medicinal chemistry letters
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Bioorg. Med. Chem. Lett. · Mar 2008
In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.
Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. O-Alkyl, N-desmethyl, and non-phenol containing derivatives of tramadol were synthesized to probe their effect on metabolic stability and both in vitro and in vivo potency.