Journal of vascular and interventional radiology : JVIR
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J Vasc Interv Radiol · Dec 2002
Multicenter Study Clinical TrialTreatment of occluded central venous catheters with alteplase: results in 1,064 patients.
Thrombosis of central venous access devices (CVADs) is a relatively frequent complication. Alteplase (tissue plasminogen activator) has been used to salvage dysfunctional devices. The purpose of this study was to analyze the safety and efficacy of alteplase after administration of a maximum of two 2-mg/2-mL doses to thrombosed CVADs. ⋯ A regimen of as many as two 2-mg doses of alteplase is safe and effective for restoring flow to occluded central venous access devices.