Paediatric anaesthesia
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Paediatric anaesthesia · Dec 2014
Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats.
Dexmedetomidine, a selective α2-adrenoceptor agonist, is a new sedative agent. ⋯ In spontaneously breathing immature rats, dexmedetomidine administration significantly reduced HR and V'E. Because atipamezole fully reversed decreases in fR and therefore V'E, dexmedetomidine-related respiratory suppression occurs predominantly through α2-adrenoceptor-related suppression of fR.