Paediatric anaesthesia
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Paediatric anaesthesia · Oct 2021
Case ReportsPropofol-Induced Uric Acid Crystals: A Case of Cloudy Urine.
Propofol is an intravenous anesthetic agent commonly used intraoperatively as well as in the intensive care unit. Known short-term effects of propofol can include apnea, hypotension, and bradycardia. In children, the rarer adverse sequelae of intravenous anesthetics have received little attention. We present the case of a thirteen-year-old male who incidentally developed uric acid crystals in his urine following a short-duration propofol infusion.
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Paediatric anaesthesia · Oct 2021
ReviewMidlatency Auditory Evoked Potentials during Anesthesia in Children: a Narrative Review.
The brain is considered as the major target organ of anesthetic agents. Despite that, a reliable means to monitor its function during anesthesia is lacking. Mid latency auditory evoked potentials are known to be sensitive to anesthetic agents and might therefore be a measure of hypnotic state in pediatric patients. This review investigates the available literature describing various aspects of mid latency auditory evoked potential monitoring in pediatric anesthesia.
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Paediatric anaesthesia · Oct 2021
HLA Antibodies and Their Association with Blood Product Exposures in Pediatric Patients Undergoing Cardiac Transplantation.
Previous blood product exposures may result in the development of antibodies to human leukocyte antigens (HLA). Pediatric heart transplant recipients who have these antibodies experience increased morbidity and mortality after transplantation. In this study, our aims were to confirm the association of previous allogeneic blood product exposures with the formation of anti-HLA antibodies, determine which blood components pose the greatest risk of developing antibodies, and assess differences in outcomes after transplantation between patients who had anti-HLA antibodies and those who did not. ⋯ Exposure to previous allogeneic blood products affects the development of anti-HLA antibodies in children presenting for heart transplantation. Previous RBC exposures resulted in HLA antibody positivity more than other blood component exposures. Importantly, the presence of HLA antibodies was associated with the development of DSAs post-transplantation. Developing transfusion strategies to reduce allogeneic blood product exposures in children who may need future cardiac transplantation should be a high priority.