American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Jul 2015
Randomized Controlled TrialVaginal progesterone for the prevention of preterm birth in twin gestations: a randomized placebo-controlled double-blind study.
The purpose of this study was to investigate the use of vaginal progesterone for the prevention of preterm delivery in twin pregnancies. ⋯ In nonselected twin pregnancies, vaginal progesterone administration does not prevent preterm delivery and does not reduce neonatal morbidity and death.
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Am. J. Obstet. Gynecol. · Jul 2015
Is fetal cerebroplacental ratio an independent predictor of intrapartum fetal compromise and neonatal unit admission?
We sought to evaluate the association between fetal cerebroplacental ratio (CPR) and intrapartum fetal compromise and admission to the neonatal unit (NNU) in term pregnancies. ⋯ Lower fetal CPR, regardless of the fetal size, was independently associated with the need for operative delivery for presumed fetal compromise and with NNU admission at term. The extent to which fetal hemodynamic status could be used to predict perinatal morbidity and optimize the mode of delivery merits further investigation.
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Am. J. Obstet. Gynecol. · Jul 2015
Comparative StudyPrevention and management of postpartum hemorrhage: a comparison of 4 national guidelines.
The purpose of this study was to compare 4 national guidelines for the prevention and management of postpartum hemorrhage (PPH). ⋯ Substantial variation exists in PPH prevention and management guidelines among 4 national organizations that highlights the need for better evidence and more consistent synthesis of the available evidence with regard to a leading cause of maternal death.
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We sought to determine whether young adolescents aged 11-14 years and teens aged 15-17 and 18-19 years have an increased risk of cesarean or operative delivery, as well as maternal or neonatal delivery-related morbidity, compared to young adults aged 20-24 years. ⋯ Young adolescents have a decreased risk of cesarean and operative vaginal delivery compared to young adults; however, their neonates face higher risks of preterm delivery, low and very low birthweight, and death. This information can be used to inform clinical care for this population.
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Am. J. Obstet. Gynecol. · Jul 2015
Identification of novel mechanisms involved in generating localized vulvodynia pain.
Our goal was to gain a better understanding of the inflammatory pathways affected during localized vulvodynia, a poorly understood, common, and debilitating condition characterized by chronic pain of the vulvar vestibule. ⋯ These findings implicate that a fibroblast-mediated proinflammatory response to C albicans contributes to the induction of pain in LPV cases. Targeting this response may be an ideal strategy for the development of new vulvodynia therapies.