The American journal of psychiatry
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Delirium is a common and potentially life-threatening clinical syndrome. The authors investigated resting-state functional connectivity in patients with delirium to elucidate possible neural mechanisms underlying this disorder. ⋯ These findings suggest that the disruption in reciprocity of the dorsolateral prefrontal cortex with the posterior cingulate cortex and reversible reduction of functional connectivity of subcortical regions may underlie the pathophysiology of delirium. In addition, enhanced integration in the posteromedial cortices may account for facilitating the rapid improvement of delirium.