Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Feb 2009
Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes.
It has been suggested that oxidized low-density lipoprotein (ox-LDL) has some roles in progression of osteoarthritis. The purpose of this study is to investigate whether ox-LDL binding to lectin-like ox-LDL receptor 1 (LOX-1) enhances monocyte chemoattractant protein 1 (MCP-1) expression in cultured human articular chondrocytes (HACs). ⋯ Our results suggest that ox-LDL enhances MCP-1 expression in HACs and supports the hypothesis that ox-LDL is involved in cartilage degeneration.