Human brain mapping
-
Human brain mapping · Oct 2013
Brain plasticity in the motor network is correlated with disease progression in amyotrophic lateral sclerosis.
To test the influence of functional cerebral reorganization in amyotrophic lateral sclerosis (ALS) on disease progression. ⋯ Cortical Blood Oxygen Level Dependent (BOLD) signal changes occur in the brain of ALS patients during a simple hand-motor task when the motor deficit is still moderate. It is correlated with the rate of disease progression suggesting that brain functional rearrangement in ALS may have prognostic implications.