Arthritis and rheumatism
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Arthritis and rheumatism · Jun 1998
Effect of intraarticular hyaluronan injection in experimental canine osteoarthritis.
To determine if intraarticular injections of hyaluronan (HA) protect against the early stages of joint damage in a canine model of osteoarthritis (OA). ⋯ In this canine model of OA, the series of intraarticular injections of HA did not alter development of osteophytosis or fibrillation. However, the PG concentration of cartilage in the OA knee was significantly reduced by this treatment, suggesting that HA therapy might adversely affect the biomechanical properties of the cartilage.