British journal of cancer
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British journal of cancer · Jul 2009
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion.
Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated. ⋯ Our data suggest that fibronectin-mediated activation of FAK that leads to lung cancer metastasis could occur through ERK or PI3K/Akt regulation of MMP9/calpain-2 or MMP9/RhoA activity, respectively.
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British journal of cancer · Jul 2009
Suicide in cancer patients in South East England from 1996 to 2005: a population-based study.
Studies from around the world have shown that suicide risk is increased in cancer patients, but no previous detailed analysis has been carried out in England. ⋯ There is a critical period immediately after the diagnosis of cancer during which the excess risk of suicide is particularly high. Carers need to be aware of the importance of attending to both the physical and emotional needs of cancer patients and cancer survivors.