Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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Ann. Allergy Asthma Immunol. · Nov 2013
Effect of exogenous interferons on rhinovirus replication and airway inflammatory responses.
Human rhinoviruses (HRVs) are the most common cause of asthma exacerbations. In airway epithelial cells, the primary site of HRV infection, decreased production of interferons (IFNs) may result in greater susceptibility to HRV and worsened symptoms. Thus, exogenous IFN could supplement the innate immune response and provide a treatment for virus-induced asthma exacerbations. Furthermore, the effects of exogenous IFN could be type specific in part because of the cellular distribution of type 1 and type 2 IFN receptors. ⋯ These findings suggest that exogenous IFNs, IFN-λ1 in particular, warrant further study as a potential therapy for virus-induced asthma exacerbations.
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Ann. Allergy Asthma Immunol. · Oct 2013
Wheeze phenotypes in young children have different courses during the preschool period.
Rules for predicting the course of asthma in wheezy infants have low specificity. ⋯ These results show that remission is most frequently observed in mild EVW and that no remission is observed in atopic MTW.