Journal of pediatric hematology/oncology
-
J. Pediatr. Hematol. Oncol. · Mar 2008
Comparative StudyClot strength: a comparison between cord and adult blood by means of thrombelastometry.
To evaluate the clot strength in cord versus adult blood. ⋯ Neonatal fibrin shows impaired polymerization properties under our experimental conditions resulting in reduced clot strength compared with fibrin of adult origin.
-
J. Pediatr. Hematol. Oncol. · Feb 2008
Hearing loss in pediatric oncology patients receiving carboplatin-containing regimens.
Carboplatin is a well-established chemotherapeutic agent used to treat a variety of pediatric malignancies. Platinum analogues such as cisplatin are known to be ototoxic, but little is known regarding the ototoxicity of carboplatin. We performed a single institution retrospective chart review of pediatric oncology patients who received platinum-containing regimens from 1993 to 2002. ⋯ In contrast, 19/27 (70%) of patients receiving carboplatin and cisplatin possessed significant hearing loss, as did 27/47 (57%) of those patients receiving cisplatin only P<0.001. The difference in hearing loss could not be explained by different cumulative exposures of the platinum agents. Carboplatin, when used without cisplatin, is rarely associated with severe hearing loss, even at high cumulative doses.
-
J. Pediatr. Hematol. Oncol. · Feb 2008
Randomized Controlled TrialSedative preference of families for lumbar punctures in children with acute leukemia: propofol alone or propofol and fentanyl.
Propofol is a common sedative/anesthetic used for invasive procedures in children with cancer. The purpose of this study was to determine whether families of children with acute leukemia prefer propofol alone or propofol plus fentanyl for lumbar puncture (LP) sedation. We conducted a randomized, placebo controlled, double blind, crossover study. ⋯ Sixteen families (72.7%) chose propofol with fentanyl for future LP sedations (P=0.05). In conclusion, most families prefer propofol and fentanyl for LPs. Propofol with fentanyl was also associated with fewer adverse events and faster recovery.
-
J. Pediatr. Hematol. Oncol. · Jan 2008
Case ReportsOndansetron-associated hypokalemia in a 2-year-old with pre-B-cell ALL.
Ondansetron is a commonly used medication in the treatment of nausea and vomiting arising from many etiologies, including chemotherapy. Although it is a highly safe drug, ondansetron use has been associated, rarely, with hypokalemia. ⋯ We relate a patient who presents with hypokalemia of unknown etiology, with evidence suggesting a possible relationship to ondansetron. We also present a proposed mechanism for this phenomenon.
-
J. Pediatr. Hematol. Oncol. · Dec 2007
Case ReportsDiaphragmatic mesothelial cyst in a child with Fanconi aplastic anemia.
Fanconi aplastic anemia (FAA), an inherited form of bone marrow failure syndrome, is characterized by progressive bone marrow failure and high risk of developing a malignancy. One or more congenital malformations may be detected in at least 90% of the affected individuals. Despite many forms of congenital malformations in FAA, there are no reports of coexisting FAA and diaphragmatic mesothelial cyst. Here, we report a 7-year-old female patient with FAA is associated with diaphragmatic mesothelial cyst.