European journal of neurology : the official journal of the European Federation of Neurological Societies
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Comparative Study Clinical Trial
Battery lifetime in pallidal deep brain stimulation for dystonia.
The aim of the study was to analyse the lifetime of Soletra implantable pulse generators (IPG) in deep brain stimulation (DBS) of the globus pallidus internus (GPi) for dystonia, depending on stimulation parameters and the total electrical energy delivered (TEED) by the IPG. ⋯ Battery lifetime in GPi DBS for dystonia is substantially shorter compared with that reported in DBS for Parkinson's disease, caused by a considerably higher voltage and greater pulse width and therefore a higher TEED applied during the battery lifetime cycle. The commonly used equation to calculate TEED, however, seems to be correct only for monopolar, but not bipolar stimulation.
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Previous studies reported a higher risk of cognitive decline and dementia amongst individuals with impaired lung function. However, many did not adjust for important confounders or did not include women and non-whites. ⋯ Reduced lung function was associated with worse performance in cognitive assessments and with an increased risk of dementia hospitalization. Future research should determine whether maintaining optimal pulmonary health might prevent cognitive impairment and dementia.
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Randomized Controlled Trial
Gabapentin for the treatment of carpal tunnel syndrome: a randomized controlled trial.
Based on its efficacy in treating neuropathic pain, gabapentin may be effective for the treatment of carpal tunnel syndrome (CTS). The purpose of this study was to evaluate the efficacy of gabapentin for symptom relief in CTS. ⋯ Gabapentin did not produce a significant reduction in symptom severity compared with placebo over an eight-week period.
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Comparative Study
Impaired neurovascular coupling in ischaemic stroke patients with large or small vessel disease.
There is limited data of neurovascular coupling on stroke patients, especially on comparison of different etiologies. We aim to test the hypothesis that patients with small vessel disease (SVD) are impaired on neurovascular coupling rather than stroke patient with large intracranial artery stenosis (LIAS), because small vessel is more associated with microcirculatory function. To assess microcirculatory integrity of stroke patients, we performed a functional transcranial Doppler test using a standardized visual stimulation test. ⋯ Interestingly, both LIAS and SVD showed an uncoupling of the blood supply of active neurons. This points to an additional small vessel dysfunction in patients with LIAS.
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Letter Case Reports
Cerebral venous sinus thrombosis in an adult with sickle β°-thalassemia.