Journal of neurovirology
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Journal of neurovirology · Dec 2016
Case ReportsNormonatremic osmotic demyelination in the setting of acquired immune deficiency syndrome and malnutrition: case report and literature review.
In this report, we present the case of a 43-year-old woman with AIDS, disseminated aspergillosis, and malnutrition who developed osmotic demyelination syndrome. AIDS-related osmotic demyelination has only been documented in a handful of cases to date, and it appears independent of the classic mechanism of rapid correction of hyponatremia. ⋯ It appears that complications of malnutrition, possibly related to depletion of organic osmolytes in the central nervous system, may place AIDS patients at greater risk of osmotic demyelination. These, and other proposed mechanisms, deserve further inquiry.