Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
Rifabutin-Based Triple Therapy (RHB-105) for Helicobacter pylori Eradication: A Double-Blind, Randomized, Controlled Trial.
Although consensus supports eradication of Helicobacter pylori infections, antimicrobial resistance has substantially reduced eradication rates with most current therapies. ⋯ RedHill Biopharma Ltd.
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Comment
In COVID-19, adding lopinavir-ritonavir to usual care did not shorten time to clinical improvement.
Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382:1787-99. 32187464.
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Comment
In MRSA bacteremia, adding a β-lactam to usual care did not improve a composite outcome at 90 days.
Tong SY, Lye DC, Yahav D, et al. Effect of vancomycin or daptomycin with vs without an antistaphylococcal β-lactam on mortality, bacteremia, relapse, or treatment failure in patients with MRSA bacteremia: a randomized clinical trial. JAMA. 2020;323:527-37. 32044943.